Association of Serum Ferritin with Risk of Anemia in Non-Diabetic Adolescents with Family History of Type 2 Diabetes Mellitus

Authors

  • Maira Mahmood Department of Biochemistry, FMH College of Medicine and Dentistry, Lahore, Pakistan https://orcid.org/0000-0002-0459-2598
  • Huma Ashraf Department of Biochemistry, CMH Lahore Medical College, Lahore, Pakistan
  • Anoosh Qayyum Department of Biochemistry, Ameer ud din Medical College, Lahore, Pakistan
  • Farwa Sijjeel Department of Hematology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Naim Ahmad Nizami Department of Biochemistry, Rai Medical College, Sargodha, Pakistan
  • Shazia Rashid Institute of Molecular Biochemistry and Biotechnology, Univeristy of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.53685/jshmdc.v2i2.77

Keywords:

ferritin, insulin resistance, type 2 diabetes mellitus

Abstract

Background: Controversy occurs in the relationship between serum ferritin levels, insulin resistance and risk of developing anemia in adolescents with family history of diabetes.

Aims & Objectives: This study was designed to find out the association between serum ferritin levels with risk of developing anemia in non-diabetic adolescents with family history of type 2 diabetes mellitus (T2DM).

Materials & Methods: A descriptive cross-sectional was conducted in a local medical institute of Lahore. Study included 50 non-diabetic, non-obese male / female adolescent with family history of type 2 diabetes mellitus and 50 healthy male/female non-obese adolescents without family history of T2DM considered as controls. Level of serum ferritin and serum insulin was estimated by Enzyme Linked Immunosorbent Assay. Blood glucose was estimated by auto-analyzer. Insulin resistance was calculated by HOMA-IR index and beta cell function was assessed by HOMA- beta index.

Results: Levels of fasting blood sugar, insulin resistance were found to be increased with decreased level of serum ferritin and decrease beta cell function in both male as well as female cases as compared to controls. Negative correlation was found between serum ferritin and insulin resistance while a positive correlation was found between serum ferritin and beta cell function.

Conclusions: Low level of serum ferritin is associated with reduced beta cell function and increased insulin resistance. This may increase the risk of developing iron deficiency anemia that can affect both immune system as well as increase susceptibility to infections.

Author Biographies

Huma Ashraf, Department of Biochemistry, CMH Lahore Medical College, Lahore, Pakistan

 

 

Farwa Sijjeel, Department of Hematology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan

 

 

Naim Ahmad Nizami, Department of Biochemistry, Rai Medical College, Sargodha, Pakistan

 

 

Shazia Rashid, Institute of Molecular Biochemistry and Biotechnology, Univeristy of Lahore, Lahore, Pakistan

 

 

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Published

12/30/2021

Issue

Vol. 2 No. 2 (2021): July-December 2021

Section

Original Articles

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Copyright (c) 2021 Maira Mahmood, Huma Ashraf, Anoosh Qayyum, Farwa Sijjeel, Naim Ahmad Nizami, Shazia Rashid

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