Association of Serum Ferritin with Risk of Anemia in Non-Diabetic Adolescents with Family History of Type 2 Diabetes Mellitus

Authors

  • Maira Mahmood FMH college of Medicine and Dentistry,Lahore https://orcid.org/0000-0002-0459-2598
  • Huma Ashraf CMH Lahore Medical College, lahore
  • Anoosh Qayyum Ameer ud din Medical College,Lahore
  • Farwa Sijjeel Pakistan Institute of Medical Sciences, Islamabad
  • Naim Ahmad Nizami Rai Medical College, Sargodha
  • Shazia Rashid Univeristy of Lahore, Lahore

DOI:

https://doi.org/10.53685/jshmdc.v2i2.77

Keywords:

ferritin, insulin resistance, type 2 diabetes mellitus

Abstract

Background: Controversy occurs in the relationship between serum ferritin levels, insulin resistance and risk of developing anemia in adolescents with family history of diabetes.

Aims & Objectives: This study was designed to find out the association between serum ferritin levels with risk of developing anemia in non-diabetic adolescents with family history of type 2 diabetes mellitus (T2DM).

Materials & Methods: A descriptive cross-sectional was conducted in a local medical institute of Lahore. Study included 50 non-diabetic, non-obese male / female adolescent with family history of type 2 diabetes mellitus and 50 healthy male/female non-obese adolescents without family history of T2DM considered as controls. Level of serum ferritin and serum insulin was estimated by Enzyme Linked Immunosorbent Assay. Blood glucose was estimated by auto-analyzer. Insulin resistance was calculated by HOMA-IR index and beta cell function was assessed by HOMA- beta index.

Results: Levels of fasting blood sugar, insulin resistance were found to be increased with decreased level of serum ferritin and decrease beta cell function in both male as well as female cases as compared to controls. Negative correlation was found between serum ferritin and insulin resistance while a positive correlation was found between serum ferritin and beta cell function.

Conclusions: Low level of serum ferritin is associated with reduced beta cell function and increased insulin resistance. This may increase the risk of developing iron deficiency anemia that can affect both immune system as well as increase susceptibility to infections.

Author Biographies

Maira Mahmood, FMH college of Medicine and Dentistry,Lahore

Associate Professor

Biochemistry Department

Huma Ashraf, CMH Lahore Medical College, lahore

Associate Professor

Department of Biochemistry

Anoosh Qayyum, Ameer ud din Medical College,Lahore

Assistant Professor

Farwa Sijjeel, Pakistan Institute of Medical Sciences, Islamabad

Department of Hematology

Assitant Professor

Naim Ahmad Nizami, Rai Medical College, Sargodha

Professor

Department of Biochemistry

Shazia Rashid, Univeristy of Lahore, Lahore

Associate Professor

Institute of Molecular Biochemistry and Biotechnology

 

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Published

12/30/2021

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Section

Original Articles