Spontaneous Abortions and Gestational Diabetes Mellitus- A Study from Pakistan

Authors

  • Aasia Kanwal University of Health Sciences, Lahore, Pakistan
  • Asma Salam University of Health Science, Lahore, Pakistan
  • Aisha Bashir University of Health Sciences, Lahore, Pakistan

DOI:

https://doi.org/10.53685/jshmdc.v2i2.75

Keywords:

Spontaneous abortios, Maternal hyperglycemia, Gestational Diabetes Mellitus

Abstract

Background: Gestational diabetes mellitus leads to adverse pregnancy outcomes.

Objectives: The objective of the study was to explore the relationship of spontaneous abortions with gestational diabetes mellitus in pregnant women from rural and urban Lahore.

Methods: This cross-sectional study was conducted at University of Health Sciences, Lahore in 2019. Among 60 pregnant women sampled, 30 had gestational diabetes mellitus (GDM) and 30 were normal pregnant controls. Pregnant women were sampled from different hospitals of rural and urban areas of Lahore. Independent sample t-test was applied for analyzing the data. Chi- square test was used to analyze the categorical variables. Association of fasting blood glucose (FBG) and abortions was checked. Odd ratio and relative risk were calculated.

Results: Mean fasting blood sugar levels were significantly higher in GDM group (105 mg/dL) as compared to non-GDM group (80.50 mg/dL) at p<0.001. The proportions of the women with increased number of abortions had significantly higher blood glucose levels (OR 5.091, 95% CI, RR 1.27).

Conclusions: Gestational diabetes mellitus is associated with an increased risk of spontaneous abortions.

References

Natamba BK, Namara AA, and Nyirenda MJ. Burden, risk factors and maternal and offspring outcomes of gestational diabetes mellitus (GDM) in sub-Saharan Africa (SSA): a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019; 19(1): 450.

Lee HJ, Norwitz E, Lee B. Relationship between threatened miscarriage and gestational diabetes mellitus. BMC Pregnancy Childbirth. 2018; 18(1): 318.

Peters SAE, Yang L, Guo Y, Chen Y, Bian Z, Sun H, et al. Pregnancy, pregnancy loss and the risk of diabetes in Chinese women: findings from the China Kadoorie Biobank. Eur. J. Epidemiol. 2020; 35(3): 295-303.

Alves C, Rapp A. Spontaneous abortion 12th Ed. StatPearls Publishing LLC; 2021.P218-225.

American College of Obstetricians and Gynecologists. The American College of Obstetricians and Gynecologists practice bulletin no.

Early pregnancy loss. Obstet. Gynecol. 2015; 125(5): 1258-1267.

Lawn JE, Blencowe H, Waiswa P, Amouzou A, Mathers C, Hogan D, et al. Stillbirths: rates, risk factors, and acceleration towards 2030. The Lancet. 2016; 387(10018): 587-603.

Kleinberger JW, Maloney KA, Pollin TI. The genetic architecture of diabetes in pregnancy: implications for clinical practice. Am J Perinatol. 2016; 33(13): 1319-1326.

Ruchat SM, Mottola MF. The important role of physical activity in the prevention and management of gestational diabetes mellitus. Diabetes Metab Res Rev. 2013; 29(5): 334-346.

Mohan MA, Chandrakumar A. Evaluation of prevalence and risk factors of gestational diabetes in a tertiary care hospital in Kerala. Diabetes Metab Syndr. 2016; 10(2): 68-71.

Federation ID, Atlas ID. International Diabetes Federation. IDF diabetes atlas, 6th edn Brussels, Belgium: Diabetes Res Clin Pract. 2013.

Calleja-Agius J, Calleja N, Brincat M, Spiteri D. Obstetric outcome in cases of threatened spontaneous abortion. Int J Gynaecol Obstet. 2010; 110(1): 75-76.

Feleke BE. Determinants of gestational diabetes mellitus: a case-control study. J Matern Fetal Neonatal Med. 2018; 31(19): 2584-2589.

Tian L, Shen H, Lu Q, Norman RJ, Wang J. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment. The Journal of Clinical Endocrinology & Metabolism. 2007; 92(4): 1430-1433.

Yaping X, Chunhong L, Huifen Z, Fengfeng H, Huibin H, Meijing Z. Risk factors associated with gestational diabetes mellitus: a retrospective case-control study. Int. J. Diabetes Dev. Ctries. 2021:1-10.

Han Y, Tong M, Jin L, Yu J, Meng W, Ren A. Maternal age at pregnancy and risk for gestational diabetes mellitus among Chinese women with singleton pregnancies. Int. J. Diabetes Dev. Ctries. 2021; 41(1): 114-120.

Luo X, Zhu Y, Chen L, Wang Y. Analysis of risk factors for gestational diabetes mellitus and its effect on pregnancy outcome. Chin. J. Pri. Med. Pharm. 2016;23(18):2728-2731.

Cefalu WT, Berg EG, Saraco M, Petersen MP, Uelmen S, Robinson S. Classification, and diagnosis of diabetes: standards of medical care in diabetes- 2019. Diabetes Care. 2019; 42: S13-S28.

Woticha EW, Deressa W, Reja A. Prevalence of gestational diabetes mellitus and associated factors in

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Published

12/30/2021

How to Cite

1.
Kanwal A, Salam A, Bashir A. Spontaneous Abortions and Gestational Diabetes Mellitus- A Study from Pakistan. J Shalamar Med Dent Coll [Internet]. 2021 Dec. 30 [cited 2024 Nov. 28];2(2):58-63. Available from: https://journal.smdc.edu.pk/index.php/journal/article/view/75

Issue

Vol. 2 No. 2 (2021): July-December 2021

Section

Original Articles

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Copyright (c) 2021 Aasia Kanwal, Asma Salam, Aisha Bashir

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